Pregnenolone Review – Does It Really Work?

A neurohormone called pregnenolone is perfect for anyone who wants to retain youthful hormone levels, brain clarity, memory health, and other things.
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What is Pregnenolone?

Life Extension Pregnenolone is a supplement made for people looking to enhance their brain cognition processes and other functions. The manufacturers are committed to creating cutting-edge supplements with claims that their products optimize health and general body performance.

Originally, pregnenolone is an important hormone that can be found naturally in cholesterol in the body. The steroid hormone plays an essential role in the production of other vital hormones such as DHEA, progesterone, and estrogen.

Over the years, the hormone has been made into supplements; it is said to help the functionality of the naturally produced Pregnenolone. The supplement also plays an essential role in enhancing brain performance, learning, and memory.


Editor’s Rating
3.3 / 5.0
Overall Rating

Brand Highlights

  • Enhancing Brain Performance.
  • Support and Maintain the Brain’s Health.
  • Improve the Level of Learning and Memory.

Shop On AmazonShop On Walmart*All the prices mentioned on their websites are subject to change.

  • 3.1/ 5


  • 2.9/ 5

    Value For Cost

  • 3.3/ 5


  • 3.0/ 5



Manufacture Life Extension.
Made In Fort Lauderdale, FL 33304.
Type Memory supplement.
Serving Size Take 1 Capsule Daily.
Eve 100 Capsules.
Main Benefits Improved focus and concentration, Increased creativity, Enhanced memory, and learning.
Key Ingredient Pregnenolone Ionized.
Allergen Warning Not Available.
Safety Information Pregnant or breastfeeding women are generally advised to avoid using Alpha Brain.
Price 30-Day Supply: $19.50

” Pregnenolone Benefit/ Cognitive Health Digest.

About Manufacturer

Life Extension Pregnenolone is manufactured by Life Extension, Inc., a company that has been in business for over 40 years and sells vitamins, supplements, and other health products. Life Extension claims to use science-backed ingredients and dosages in its products and offers a 12-month satisfaction guarantee.

They are a popular brand among people who are looking for natural ways to improve their health. Some of their most popular products include multivitamins, omega-3 fatty acids, and probiotics. They also sell a variety of products for specific health concerns, such as joint pain, heart health, and weight loss.

Life Extension is a legitimate company with a good reputation. They are a preferred brand of the third-party testing organization However, it is important to note that supplements are not regulated by the FDA, so it is always important to talk to your doctor before taking any new supplements.

What are the Pregnenolone’s Claims?

The manufacturers of this product claim that by complementing the natural pregnenolone produced in the body, Life Extension Pregnenolone increases body mood. It then gives a resultant reduction in the level of anxiety and depression.

This product promises to improve the amount of time the body rests in a deep sleep, which in turn helps with memory.

Another benefit of this supplement as stated by the producers is that it helps to relieve fatigue, stress, and other factors reducing the brain’s output. In addition to its many functions, Life Extension Pregnenolone may relieve unpleasant menopausal symptoms in women.

What are the Key Ingredients and How do They Work?

VLife Extension’s Pregnenolone Microtabs are formulated mainly with the laboratory-made pregnenolone hormone. The supplement, however, contains the following:

Pregnenolone Ionized

Pregnenolone works by stimulating and inhibiting certain neuronal activities in the brain.[1]Its ability to alter neuronal activities in the brain helps it to modulate two critical nerve receptor systems in the brain: The NMDA receptors, which are responsible for learning, memory, and sharpness, as well as the GABA receptors, which are responsible for sleep and mood activities.[2]

It also allows it to act as a precursor for other hormones in the body, such as testosterone, cortisol, DHEA, and estrogen.

Phosphatidylserine supplement-fact

” Phosphatidylserine Supplement-Fact.

Vegetable Cellulose

This substance is used as an additive agent in supplements. It enhances the metabolism and absorption of the supplement. It is refined from its raw form called wood pulp to the consumable vegetable cellulose.

White Rice Flour

This is a popular excipient in formulating several supplements. Rice flour is rich in fiber,[3] and it helps the body to rid itself of metabolic waste.

Rice Extract

Just like white rice flour, rice extract is used as a filler. As rice contains choline, a nutrient that aids the transportation of cholesterol and triglycerides from the liver to where they’re needed in the body.

Pregnenolone Benefits

  • Helps maintain healthy hormone levels
  • Helps maintain mental focus & memory health
  • Supports a healthy mood

How We Researched & Rated

Based on scientific research and evidence, below is the score of how likely Pregnenolone will be effective for their claimed benefits:

  • Support Brain Health3.4/5
  • Improve Focus & Concentration3.2/5
  • Boosting the Mental Performance3.6/5
  • Improve Cognitive Performance3.3/5

We used the insights from our research and testing to assign a star rating from one to five (five being the best; one being the worst) to this product.

Pros and Cons of Pregnenolone


  • It helps to slow down the aging of the brain by producing new synapses from time to time.
  • It helps in the maintenance of memory and preventing age-related memory impairment.
  • Helps to maintain a healthy brain.
  • It improves the overall mood of the body.


  • Pregnenolone has been known to trigger some side effects such as mood swings, headache, and anxiety.
  • It may also cause sleep issues ranging from mild to severe.
  • Due to the body’s physiological reaction to pregnenolone, consumers may suffer hormone-sensitive conditions.

Product Comparison

To help you decide, here is a brief comparison of our top picks:

Table of Content Mind lab pro Alpha brain Pregnenolone
Image mind lab pro alpha-brain Pregnenolone
Rating 4.8 / 5.0 4.9 / 5.0 3.3 / 5.0
Price $69.10 $34.95 $19.50
Sold By Opti-Nutra Ltd Onnit Life Extension
Age Range Adult Adult Adult
Brand Name Opti-Nutra Ltd Onnit Life Extension
Dosage 2 Capsule 1 Capsule 7 Capsule
Ingredients Bacopa Monnieri L-Theanine Pregnenolone Ionized
Unit Count 60 Capsule 90 Capsule 100 Capsule
Where To Find Read More Read More Read More

Can Pregnenolone Improve Your Brain’s Performance?

As every human gets older, definitely the natural level of Pregnenolone that the body produces will decline, therefore, supplementation of the natural pregnenolone must be provided to support and maintain the brain’s health, especially in memory retention and healthiness.

Pregnenolone has proven over time to improve the level of learning and memory.

Pregnenolone also involves the modification of the NMDA receptors, which is included in the maintenance of the learning and memory functions of the brain.


” Pregnenolone Benefit/ Cognitive Health Digest.

It also helps to maintain the brain and protect it from aging-related memory loss.

It also aids in the production of myelin, which is a fatty layer that insulates nerves, leading to the formation of new synapses that acts as a neuroprotector, from time to time.

It has also been proved that Pregnenolone helps in activating the dopamine receptor, which invariably improves the brain and sets the body in a better mood.


What is the Return and Exchange Policy?

A: Life Extension has a 60-day refund policy which asserts that all purchases made from the official website can be returned within 60 days after purchase. The buyer gets a 100% refund as long as the product is returned unused and unopened within 60 days.

How Should You Use Pregnenolone?

A: The supplement comes in three kinds of dosages: 10 mg, 25 mg, and 100 mg. Each bottle contains 100 capsules.
One should be taken one capsule per day, during a meal. It is best taken early in the morning. Also, it can be used at night, right before sleep.

How Much Does It Cost?

A: You can buy Life Extension Pregnenolone on the official website or from their store. The 100mg capsule bottle sells for $19.59 respectively on Life, which is a relatively low price.

Pregnenolone Review – Final Thoughts

Pregnenolone has helped some consumers to improve their brain and general body function. In addition to its significant impact on mood, the supplement boosts learning and memory.

However, several claims showed that Life Extension Pregnenolone might not work for everyone. Pregnenolone may increase anxiety for some people. It may also cause sleep issues ranging from mild to severe.

We believe that there are areas in which the manufacturers can improve to serve the purpose it claims to do without adverse side effects.


More than ever people of all ages are struggling with memory problems. People are unable to disconnect from their work, while students are under immense pressure to perform. Brains are overloaded with information that must be remembered. A quality memory enhancement product should contain clinically proven ingredients that will help to enhance not only memory, but also focus and night concentration. Memory products should help to optimize overall mental health and brain function. Most importantly a memory product should work safely and gently to promote cognitive function.

Below you'll find some of the most effective memory products on the market today, in our opinion.

Rating Table

Our Top Memory Supplements Choices



Noocube Overall rating 4.9/5 Overall rating Read Full Review
  • Support Brain HealthSupport Brain Health
  • Improve Focus & ConcentrationImprove Focus & Concentration
  • Safe & EffectiveSafe & Effective
  • Money-Back GuaranteeMoney-Back Guarantee
  • Quality of IngredientsQuality of Ingredients


  • Gain a Laser-Like Focus.
  • Hone Your Problem-Solving Techniques.
  • Increasing Memory and Mental Clarity.
  • Reduce Brain Fog Brought by By Weariness.


  • NooCube is only available through the manufacturers website.
  • Expensive and difficult to buy
Bottom Line

Noocube is a reputed dietary supplement and a well-tested nootropic made with all-natural ingredients. It boosts brain functions like memory and slows down neurodegeneration and brain aging. Such properties make it a perfect supplement for prolonged use.

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Alpha Brain

Alpha Brain Overall rating 4.8/5 Overall rating Check Price
  • Support Brain HealthSupport Brain Health
  • Improve Focus & ConcentrationImprove Focus & Concentration
  • Safe & EffectiveSafe & Effective
  • Money-Back GuaranteeMoney-Back Guarantee
  • Quality of IngredientsQuality of Ingredients


  • Ideal for both men and women to enhance their focus and cognitive speed.
  • Helps support memory, mental speed and focus to promote lasting mental clarity.
  • Formulated with high-quality nutrients to help support focus.
  • Help reduce memory fog.


  • Greater cost.
  • Side effects include nausea and vomiting.
Bottom Line

Onnit Alpha Brain Collection is a set of supplements developed using the thinking and focus formula. This collection includes dietary supplements as capsules in addition to Alpha Brain Instant formulations and focus shots.

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Nootrogen Overall rating 4.7/5 Overall rating Check Price
  • Support Brain HealthSupport Brain Health
  • Improve Focus & ConcentrationImprove Focus & Concentration
  • Safe & EffectiveSafe & Effective
  • Money-Back GuaranteeMoney-Back Guarantee
  • Quality of IngredientsQuality of Ingredients


  • The formula supports cognition and focus.
  • The brain supplement helps reduce stress and anxiety, enabling you to remain calm.
  • It helps increase productivity and learning performance.
  • Nootrogen helps improve memory and the ability to concentrate.


  • The only place to get Nootrogen is online at the official website.
  • Individual results may vary depending on a variety of physical factors.
Bottom Line

Nootrogen is a dietary nootropic supplement to boost brain function, memory, concentration, focus, and energy. The nutrient booster formula supports cognitive function without causing side effects.

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BrainPill Overall rating 4.7/5 Overall rating Check Price
  • Support Brain HealthSupport Brain Health
  • Improve Focus & ConcentrationImprove Focus & Concentration
  • Safe & EffectiveSafe & Effective
  • Money-Back GuaranteeMoney-Back Guarantee
  • Quality of IngredientsQuality of Ingredients


  • Scientifically-backed ingredients.
  • Discounts with larger orders.
  • 60-day money-back guarantee.
  • Antioxidants support a healthy brain long-term.


  • Free shipping only on larger orders.
  • Some ingredients lack strong evidence for their effects.
Bottom Line

Brain Pill is a widely popular supplement that boosts mental health and cognitive abilities. It is formulated with some effective natural ingredients which improved your focus by enhancing blood circulation in the brain cells. It not only improves your mental alertness but also reduce declines in brain function.

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PrimeGENIX CortiSync

PrimeGENIX CortiSync Overall rating 4.7/5 Overall rating Check Price
  • Support Brain HealthSupport Brain Health
  • Improve Focus & ConcentrationImprove Focus & Concentration
  • Safe & EffectiveSafe & Effective
  • Money-Back GuaranteeMoney-Back Guarantee
  • Quality of IngredientsQuality of Ingredients


  • Begins balancing cortisol in 2 weeks.
  • Boost strength and energy and strength.
  • Improve the body's working.
  • Reduce hunger.
  • Improve brain health and metabolism.


  • This is a popular item that could sometimes run out of stock.
  • One can only buy it online, not in stores.
Bottom Line

Cortisync is a dietary supplement made from natural ingredients that is meant to lower cortisol levels. It uses a combination of adaptogens that stop your body from reacting to stress and lower cortisol levels.

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Brain C-13

Brain C-13 Overall rating 4.7/5 Overall rating Check Price
  • Support Brain HealthSupport Brain Health
  • Improve Focus & ConcentrationImprove Focus & Concentration
  • Safe & EffectiveSafe & Effective
  • Money-Back GuaranteeMoney-Back Guarantee
  • Quality of IngredientsQuality of Ingredients


  • It helps you stay sharp and focus.
  • It improves your memory recall.
  • It improves circulation and increases the flow of oxygen.
  • It helps in improving your cognitive health.
  • It plays a role in quick thinking


  • You cannot use the supplement if you are under the age of 18.
  • Pregnant women cannot use the supplement.
  • The official website does not have any information about the side effects of the supplement
Bottom Line

Brain C-13 is a unique supplement by Zenith Labs that improves brain health and shields the brain from harmful chemical compositions by drastically improving your memory and keeping your mind razor-sharp.

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**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy.

*Result may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. The information contained in this website is provided for general informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. Always consult your doctor before using any supplements.

*Disclosure of Material connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: “Guides Concerning the Use of Endorsements and Testimonials.”


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Customer Reviews for pregnenolone

Pregnenolone Review – Does It Really Work?
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